Platelet Rich Fibrin (PRF-L)

Platelet Rich Fibrin-Leukocytes (PRF-L) is derived from the concentration of your blood platelets and white blood cells (anti-infection). Unlike other platelet concentrates, this technique does not require any anticoagulants or bovine thrombin or other gelling agent. It is completely natural with no added chemicals. The protective membranes and socket plugs that are produced stimulate bone and soft tissue growth, accelerating soft tissue and bone healing. Unlike the conventional collagen barrier membranes that we routinely use and which work very well, PRF-L membranes are made from your own cells, not manufactured from animal products. Additionally, collagen membranes are only barriers and have no biological healing factors to speed your recovery and shorten your healing time. The PRF-L membrane and socket plugs contain a large quantity of proteins specialized in increasing cell attachment to soft tissue and titanium. With the release of these proteins, healing is more rapid and more effective. The main property of this biomaterial is the slow release of these proteins from the PRF-L material over seven to ten days which continues to accelerate the healing phase.

The PRF-L method is based on a technique that has been in use for the past ten years in France and introduced in the United States this year by its originator, Dr. Joseph Choukroun. He developed a very specific centrifuge that is a critical part of the process. To create the PRF-L material, we take a small quantity of your blood and centrifuge it in the office. This concentrates your platelets and white blood cells (leukocytes) from which the PRF-L products are made; the platelet concentrate is placed in a special tray that automatically produces membranes or socket plugs of a constant size and thickness from your cells. The average amount of blood that is taken is one to two ounces.

These membranes and socket plugs are rich in leukocytes and blood vessel growth factors (VEGF). PRF-L initiates the sustained release of platelet-derived growth factor (PDGF), a protein that plays a significant role in new blood vessel formation. Also released is transforming growth factor (TGF), a protein that stimulates tissue growth; and another protein, thrombospondin 1, an adhesive glycoprotein that aids cell interactions.